The first flights were between Miami and Puerto Rico using Curtiss C-46 and Douglas DC-4 aircraft. In 1951 it expanded services to serve New York City. Then the route system was expanded to include Chicago and Detroit. In 1960 two Douglas DC-7 were added to the fleet and with those aircraft were used for charter flights to Europe, including charters for the military.
The freight schedule was augmented by charter flights to South America and the military but by 1981 Airlift International went into Chapter 11 bankruptcy for reorganization. Following the reorganization the DC-8-54, the Fairchild FH-227 and F-27 models were used.
Due to financial problems during 1990 and 1991, Airlift International ceased operations in June 1991.[3]