Locations of the 2021 Belarusian Premier League teams
The bottom two teams from the 2020 season (Belshina Bobruisk and Smolevichi) were relegated to the First League (both relegated after one-year in the top flight). They were replaced by Sputnik Rechitsa (promoted to the top-flight for the first time in their history) and Gomel (promoted after a one-year absence), champions and runners-up of the 2020 Belarusian First League respectively.
In the winter 2020/21, Gorodeya (who finished 13th last year) dissolved and left a Premier League spot vacant. Smorgon (6th-placed team of last year's First League season, promoted after an eleven-year absence) were admitted to fill the vacancy, after Krumkachy Minsk (First League 3rd-placed team) were denied Premier League license, and another two clubs (Arsenal Dzerzhinsk and Lokomotiv Gomel) rejected the opportunity due to insufficient financing.
Energetik-BGU spent the season at City Stadium in Borisov due to league's requirement to play on natural grass pitch in the summer. In addition, four games played at RCOP-BGU Stadium in Minsk.
Isloch spent the season at City Stadium in Molodechno due to league's requirement to play on natural grass pitch in the summer. In addition, four games played at FC Minsk Stadium in Minsk.