The 2021–22 season was the 129th season in the existence of VfB Stuttgart and the club's second consecutive season in the top flight of German football. In addition to the domestic league, VfB Stuttgart participated in this season's edition of the DFB-Pokal.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.