The 2021–22 season was the 111th season in the existence of Grenoble Foot 38 and the club's third consecutive season in the second division of French football. In addition to the domestic league, Grenoble participated in this season's edition of the Coupe de France.
Players
First-team squad
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.