The winners from the First Round will play against 16 clubs that received a bye to this round. The draw was conducted on 17 June 2011. Matches of this round were played on 29 June 2011. Due to scheduling conflicts with qualifying rounds of UEFA Champions League and Europa League, games involving BATE Borisov, Minsk and Shakhtyor Soligorsk were rescheduled to 22 July, 17 August and 6 September 2011 respectively.
An open draw for quarterfinals was conducted on 21 November 2011.
Match between Lida and Naftan was moved from Lida to Grodno due to bad pitch conditions in March. Match between Klechesk and Neman was moved from Kletsk to the opponent's stadium in Grodno for similar reasons.