The 2010–11 Copa del Rey was the 109th staging of the Copa del Rey (including two seasons where two rival editions were played). The competition began on 21 August 2010 and ended on 20 April 2011 with the final, held at the Estadio Mestalla in Valencia, in which Real Madrid lifted the trophy for the eighteenth time in their history with a 1–0 victory over Barcelona in extra time. Sevilla were the defending champions, but they were defeated by Real Madrid in the semi-finals.
24 teams of 2009–10 Segunda División B. Teams that qualified are the top five teams of each of the 4 groups (excluding reserve teams) and the four with the highest number of points out of the remaining non-reserve teams (*):
18 teams of 2009–10 Tercera División. Teams that qualified are the champions of each of the 18 groups (or at least the ones with the highest number of points within their group since reserve teams are excluded):
Pot 1 teams (Segunda B and Tercera divisions) were drawn against four teams from pot 2 with the first leg at pot 1 team's home. The three remaining teams in pot 1 were paired in the same way with the pot 3 teams. The teams in the special pot 1 (Segunda A) were drawn against five teams in the special pot 2, with the first leg at the home ground of the special pot 1 teams. The remaining teams in the special pot 2 faced each other[2]
^Note: Mallorca, the fifth-placed team of the 2009–10 La Liga, were not admitted to the UEFA Europa League (initially qualified) due to their high debts. Therefore, Mallorca are in the special pot 2 and it's not on pot 3.