The 2000–01 Alpha Ethniki was the 65th season of the highest football league of Greece. The season began on 16 September 2000 and ended on 27 May 2001. Olympiacos won their fifth consecutive and 30th Greek title.
Source: Galanis Sports Data Rules for classification: 1) Points; 2) Head-to-head points; 3) Head-to-head goal difference; 4) Goal difference; 5) Goals scored; 6) Goals against; 7) Play-offs (neutral ground); 8) Draw. (Note: Criterion 7 is only used if needed to decide champion, teams for relegation or teams for UEFA competitions). (C) Champions; (O) Play-off winners; (R) Relegated Notes: