The 1921–22 League of Ireland was the inaugural season of top-tier football in the Republic of Ireland. It began on 17 September and ended on 17 December 1921.
Frankfort and YMCA withdrew from the league at the end of the season, and together with Rathmines Athletic and Reds United they make up a group of four clubs who have played just one season in the top level of the League of Ireland.[2]