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Though very similar in appearance to the .38-55 Winchester parent cartridge, the .375 Winchester cartridge has a shorter case length and operates at a higher chamber pressure of 52,000 CUP or 55,000 psi (380 MPa), compared to the .38-55 Winchester cartridge which has a longer case length and operates at a lower chamber pressure of 30,000 CUP or 35,000 psi (240 MPa).
The most commonly used bullet weights for the .375 Winchester are between 180 gr to 260 gr (11.7 g to 16.9 g) and has been used on a variety of medium to large game species such as whitetail, pronghorn, caribou, elk, moose, black bear, and brown bear.[4]