Seforanida

Seforanida
Data klinis
AHFS/Drugs.comInternational Drug Names
Rute
pemberian		Intramuskular
Kode ATC
Data farmakokinetika
Pengikatan protein80,6%
Metabolisme-
Waktu paruh eliminasi2,6 - 2,98 jam
EkskresiGinjal
Pengenal
  • Asam (6R,7R)-7-{[2-[2-(aminometil)fenil]asetil]amino}-3-
    {[1-(karboksimetil)tetrazol-5-il]sulfanilmetil}-8-okso-
    5-tia-1-azabisiklo[4.2.0]okt-2-ena-2-karboksilat
Nomor CAS
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
NIAID ChemDB
CompTox Dashboard (EPA)
Data sifat kimia dan fisik
RumusC20H21N7O6S2
Massa molar519,55 g·mol−1
Model 3D (JSmol)
  • O=C2N1/C(=C(\CS[C@@H]1[C@@H]2NC(=O)Cc3ccccc3CN)CSc4nnnn4CC(=O)O)C(=O)O
  • InChI=1S/C20H21N7O6S2/c21-6-11-4-2-1-3-10(11)5-13(28)22-15-17(31)27-16(19(32)33)12(8-34-18(15)27)9-35-20-23-24-25-26(20)7-14(29)30/h1-4,15,18H,5-9,21H2,(H,22,28)(H,29,30)(H,32,33)/t15-,18-/m1/s1 checkY
  • Key:SLAYUXIURFNXPG-CRAIPNDOSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Seforanida merupakan salah satu antibiotik sefalosporin generasi kedua.[1][2][3] Seforanida mengandung 20 atom karbon dan memiliki massa molekul relatif sebesar 519,554 Da.[4][5][6][7][8][9]

Karakteristik

Karakteristik Nilai
Jumlah akseptor hidrogen 12
Jumlah donor hidrogen 4
Jumlah ikatan rotasi 10
Koefisien partisi[10] (-{ALogP)}- -3,2
Kelarutan[11] (-{logS, log(mol/L}-)) -3,9
Permukaan kutub[12] (-{PSA}-, Å2) 244,2

Referensi

  1. ^ Crowle A, Sbarbaro J, May M (1988). "Effects of isoniazid and of ceforanide against virulent tubercle bacilli in cultured human macrophages". Tubercle. 69 (1): 15–25. doi:10.1016/0041-3879(88)90036-0. PMID 3140456.
  2. ^ Campoli-Richards D, Lackner T, Monk J (1987). "Ceforanide. A review of its antibacterial activity, pharmacokinetic properties and clinical efficacy". Drugs. 34 (4): 411–37. doi:10.2165/00003495-198734040-00001. PMID 3315624. S2CID 242440792.
  3. ^ Cone L, Barton S, Woodard D (1987). "Treatment of scleroma with ceforanide". Arch Otolaryngol Head Neck Surg. 113 (4): 374–6. doi:10.1001/archotol.1987.01860040036012. PMID 3814386.
  4. ^ Crowle AJ, Sbarbaro JA, May MH: Effects of isoniazid and of ceforanide against virulent tubercle bacilli in cultured human macrophages. Tubercle. 1988 Mar;69(1):15-25. PMID 3140456
  5. ^ Campoli-Richards DM, Lackner TE, Monk JP: Ceforanide. A review of its antibacterial activity, pharmacokinetic properties and clinical efficacy. Drugs. 1987 Oct;34(4):411-37. PMID 3315624
  6. ^ Cone LA, Barton SM, Woodard DR: Treatment of scleroma with ceforanide. Arch Otolaryngol Head Neck Surg. 1987 Apr;113(4):374-6. PMID 3814386
  7. ^ Barriere SL, Mills J: Ceforanide: antibacterial activity, pharmacology, and clinical efficacy. Pharmacotherapy. 1982 Nov-Dec;2(6):322-7. PMID 6762529
  8. ^ PMID 21059682 (PMID 21059682)
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  9. ^ PMID 18048412 (PMID 18048412)
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  10. ^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). "Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods". The Journal of Physical Chemistry A. 102 (21): 3762–3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.
  11. ^ Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). "Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices". Journal of Chemical Information and Computer Sciences. 41 (6): 1488–1493. doi:10.1021/ci000392t. PMID 11749573.
  12. ^ Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). "Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties". Journal of Medicinal Chemistry. 43 (20): 3714–3717. doi:10.1021/jm000942e. PMID 11020286.
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