Metdilazin


Metdilazin
Data klinis
AHFS/Drugs.commonograph
Kode ATC
Pengenal
  • 10-[(1-metilpirolidin-3-il) metil]- 10H-fenotiazina
Nomor CAS
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.016.220 Sunting di Wikidata
Data sifat kimia dan fisik
RumusC18H20N2S
Massa molar296,43 g·mol−1
Model 3D (JSmol)
  • S2c1ccccc1N(c3c2cccc3)CC4CCN(C)C4
  • InChI=1S/C18H20N2S/c1-19-11-10-14(12-19)13-20-15-6-2-4-8-17(15)21-18-9-5-3-7-16(18)20/h2-9,14H,10-13H2,1H3 checkY
  • Key:HTMIBDQKFHUPSX-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Metdilazin adalah antihistamin generasi pertama dengan sifat antikolinergik dari kelas fenotiazin.

Sintesis

Sintesis metdilazin:[1] R. F. Feldkamp and Y. H. Wu; Mead Johnson & Company; Templat:US Patent (1960).

Referensi

  1. ^ L. W. Marsch and R. Peterson, Arzneimittel Forsch., 9, 715 (1959).

Bacaan lebih lanjut

  • Rani Basu L, Mazumdar K, Dutta N, Karak P, Dastidar S (2005). "Antibacterial property of the antipsychotic agent prochlorperazine, and its synergism with methdilazine". Microbiol Res. 160 (1): 95–100. doi:10.1016/j.micres.2004.10.002. PMID 15782943.
  • Chattopadhyay D, Mukherjee T, Pal P, Saha B, Bhadra R (1998). "Altered membrane permeability as the basis of bactericidal action of methdilazine". J Antimicrob Chemother. 42 (1): 83–6. doi:10.1093/jac/42.1.83. PMID 9700532.
  • Chattopadhyay D, Dastidar S, Chakrabarty A (1988). "Antimicrobial properties of methdilazine and its synergism with antibiotics and some chemotherapeutic agents". Arzneimittelforschung. 38 (7): 869–72. PMID 2905130.


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